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Author: sri_mamah

Research data sharing: the EDCTP Knowledge Hub

Today, a first public version of a knowledge tool for research data sharing was presented at the EDCTP Forum. It was developed by a team from The Global Health Network. The session aimed to introduce the tool to an audience of clinical researchers and to receive as much feedback from them as possible.

Dr Michael Makanga, EDCTP Executive Director, introduced this EDCTP-funded project. Open data sharing, in general, is seen more and more as a key factor for progress in many areas. From banking to climate change, data and know-how are shared in professional fields to make faster progress by learning best practices and housing better data.

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Opening session of the Ninth EDCTP Forum

The welcoming session at a large conference is important in setting the pace for the remainder of the event. The Ninth Forum got off to a fine start on Monday evening, as it contained not only welcome messages from our Portuguese hosts, important updates on the progress of EDCTP and some inspiring keynote addresses, but also music and prizes!

Michael Makanga welcomed delegates and thanked both our hosts and the sponsoring organisations, before giving an outline of the scope of the presentations, discussions, workshops and plenary sessions that will be taking place. He announced that EDCTP´s fora will continue to be held every two years, but will in future alternate between African and European venues.

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Dr Stephan Chalon

MMV, VP Experimental Medicine & Clinical Pharmacology

Research & Development

9th EDCTP Forum, Lisbon 17-21, September

Clinical research and sustainable development in sub-Saharan Africa: the impact of North-South partnerships
The EDCTP Forum is a biennial event that provides an international platform for the presentation and discussion of frontier research to address the burden of poverty-related infectious diseases in sub-Saharan Africa, and also capacity development and networking activities to support these goals.

The EDCTP Forum attracts a diverse audience, including representatives from research institutions and universities, the larger scientific community, health care providers, governments, regional bodies, regulators, civil society and public and private research and development partners.

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12. Gonzalez R, Mombo-Ngoma G, Ouedraogo S, et al. Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Negative Women: A Multicentre Randomized Controlled Trial. PLoS Med. 2014; 11:e1001733.

Projects Malaria in Pregnancy Preventive Alternative Drugs (MiPPAD)

This project is aimed to develop new anti-malarial drugs in pregnancy prevention, promote European and African research collaboration and strengthen the research capacity of African institutions
Malaria in Pregnancy (MiP) is one of the most important preventable causes of low birth weight deliveries worldwide and a major cause of severe maternal anaemia contributing to maternal mortality. To find effective preventive interventions to reduce the incidence and consequences of malaria infection in pregnant women is a priority in endemic countries. As part of the planned activities of the Malaria in Pregnancy consortium, a global initiative bringing together a research consortium of 40 partner institutions in 28 countries around the world, this project aims not only to develop new anti-malaria in pregnancy prevention but also to promote European and to African research collaboration and to strengthen the capacity of African institutions to conduct clinical research..”

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32. Desai M, Gutman J, L’Lanziva A, et al. Intermittent screening and treatment or intermittent preventive treatment with dihydroartemisinin-piperaquine versus intermittent preventive treatment with sulfadoxine- pyrimethamine for the control of malaria during pregnancy in western Kenya: an open-label, three-group, randomised controlled superiority trial. Lancet. 2015; 386:2507-19.

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24. Gonzalez R, Augusto OJ, Munguambe K, et al. HIV Incidence and Spatial Clustering in a Rural Area of Southern Mozambique. PloS one. 2015; 10:e0132053.

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15. Mombo-Ngoma G, Mackanga JR, Gonzalez R, et al. Young adolescent girls are at high risk for adverse pregnancy outcomes in sub-Saharan Africa: an observational multicountry study. BMJ open. 2016; 6:e011783.

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16. Gonzalez R, Munguambe K, Aponte J, et al. High HIV prevalence in a southern semi-rural area of Mozambique: a community-based survey. HIV Med. 2012.

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17. Manego RZ, Mombo-Ngoma G, Witte M, et al. Demography, maternal health and the epidemiology of malaria and other major infectious diseases in the rural department Tsamba-Magotsi, Ngounie Province, in central African Gabon. BMC Public Health. 2017; 17:130.

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18. Caron M, Lekana-Douki SE, Makuwa M, et al. Prevalence, genetic diversity and antiretroviral drugs resistance-associated mutations among untreated HIV-1-infected pregnant women in Gabon, central Africa. BMC infectious diseases. 2012; 12:64.

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19. Lahuerta M, Aparicio E, Bardaji A, et al. Rapid spread and genetic diversification of HIV type 1 subtype C in a rural area of southern Mozambique. AIDS research and human retroviruses. 2008; 24:327-35.

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35. Poespoprodjo JR, Fobia W, Kenangalem E, et al. Dihydroartemisinin-piperaquine treatment of multidrug resistant falciparum and vivax malaria in pregnancy. PloS one. 2014; 9:e84976.

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13. Menendez C, Bardaji A, Sigauque B, et al. A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic. PloS one. 2008; 3:e1934.

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11. Zou GY and Donner A. Extension of the modified Poisson regression model to prospective studies with correlated binary data. Statistical methods in medical research. 2013; 22:661-70.

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37. Desai M, Gutman J, L’Lanziva A, et al. Intermittent screening and treatment or intermittent preventive treatment with dihydroartemisinin-piperaquine versus intermittent preventive treatment with sulfadoxine- pyrimethamine for the control of malaria during pregnancy in western Kenya: an open-label, three-group, randomised controlled superiority trial. Lancet. 2015.

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6. Gonzalez R, Desai M, Macete E. Intermittent Preventive Treatment of Malaria in Pregnancy with Mefloquine in HIV-Infected Women Receiving Cotrimoxazole Prophylaxis: A Multicenter Randomized Placebo- Controlled Trial. PLoS Med. 2014; 11:e1001735.

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